| Product Name | Anti-CTBP2 Antibody [PCRP-CTBP2-2D11] |
|---|---|
| Description | Mouse monoclonal [PCRP-CTBP2-2D11] antibody to CTBP2. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-CTBP2-2D11 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human CTBP2 protein. |
| Isotype | IgG2b |
| Molecular Weight | 95.2 kDa |
| Target | CTBP2 |
| Specificity | The gene CTBP2 (C-terminal binding protein 2) encodes a member of the CtBP-family. The gene is mapped to human chromosome 21q21.3. It is found to be expressed ubiquitously, with higher expression in the heart, skeletal muscle, and pancreas. The gene CTBP2 (C-terminal binding protein 2) encodes a protein that functions as a transcriptional co-repressor of several tumor suppressor genes resulting in enhanced cancer cell migration and invasion. Its expression is found to be upregulated in hepatocellular carcinoma (HCC). It may be a potential prognostic marker for post liver resection HCC. It is involved in several types of tumor initiation, progression and response to therapy. It is found to interact with the C-terminal region of adenovirus type 2/5 E1A protein, a region that negatively regulates tumorigenicity and the extent of oncogenic transformation. |
| Reactivity | Human |
| Applications | FC, IF |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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