| Product Name | Anti-CTLA4 (clone AT4F2) |
|---|---|
| Description | CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein receptor that downregulates the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Mutations in CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease and other autoimmune diseases. |
| Synonyms | Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor, CD, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12 |
| Host | Mouse |
| Clone | AT4F2. Anti-human CTLA4 mAb, clone AT4F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CTLA4 protein. |
| Immunogen | Recombinant human CTLA4 (36-161aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Dariavach. P., et al. (1988) Eur J Immunol 18(12): 1901€“1905Waterhouse. P., et al. (1995) Science 270(5238): 985€“988Magistrelli. G., et al. (1999) Eur J Immunol 29(11): 3596€“3602 |
| Supplier | ARP |
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