| Product Name | Anti-CXCL10 / IP10 Antibody [A02-1E10] |
|---|---|
| Description | Mouse monoclonal [A02-1E10] antibody to CXCL10 / IP10. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | A02-1E10 |
| Conjugate | Unconjugated |
| Immunogen | E. coli derived recombinant protein corresponding to amino acids 22-98 of human IP-10. |
| Isotype | IgG2b |
| Target | CXCL10 / IP10 |
| Amino Acid Sequence | VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP |
| Protein Length | 77 |
| Specificity | This antibody recognises the chemokine IP-10. IP-10, also known as CXCL10, is a small cytokine belonging to the CXC chemokine family. IP-10 cDNA encodes a 98 amino acid protein which is cleaved and secreted from a wide variety of cell types in response to interferon gamma and other inflammatory cytokines. IP-10 exerts its biological effects mainly via binding to CXCR3. Also, CXCR3-independent pathways have been studied for IP-10/CXCL10 involving binding to heparan sulfate glycosaminoglycans (GAGs). IP-10 not only induces chemoattraction of inflammatory cells, but also migration and proliferation of endothelial cells and VSMCs. |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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