| Product Name | Anti-CXCR4 Antibody [9D9] |
|---|---|
| Description | Mouse monoclonal [9D9] antibody to CXCR4. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 9D9 |
| Conjugate | Unconjugated |
| Immunogen | Chicken CXCR4 (chCXCR4) transfected HEK294 cells. |
| Isotype | IgG2a |
| Target | CXCR4 |
| Specificity | This antibody recognises the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin.CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Research has demonstrated that in chicks CXCR4 is expressed by cardiac neural crest cells and together with SDF-1 is involved with the migration of cells and development of the heart. Where CXCR4 function is lost, cell migration is impaired resulting in cell death and misexpression of SDF-1 leading to cardiovascular defects (Escot et al. 2013). CXCR4 expression is also linked with other development processes including cerebellar development and with vascularization of the gastrointestinal tract. Clone 9D9 provides a useful antibody for studying development biological processes.Bursa cells may be used as a positive control for CXCR4 in flow cytometry. |
| Reactivity | Gallus |
| Applications | IHC-Fr, FC, IF |
| Working Dilutions | Use 10µl of the suggested working dilution to label 1x106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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