| Product Name | Anti-Cyclin A2 (S- & G2-phase Cyclin), Monoclonal Antibody |
|---|---|
| Description | It recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk_Ûªs) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk_Ûªs. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase. |
| Synonyms | CCN1, CCNA, CCNA2, CCNA2_HUMAN, Cyclin A2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | E67 |
| Immunogen | Full length bovine Cyclin A protein |
| Isotype | IgG2a, kappa |
| Reactivity | Bovine, Human, Mink, Mouse, Primate |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 890 |
| Uniprot | P20248 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Adamczewski JP; Gannon JV; Hunt T. Simian virus 40 large T antigen associates with cyclin A and p33cdk2. Journal of Virology, 1993, 67(11):6551-7 |
| Supplier | ARP |
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