Anti-Cyclin D1 (G1-Cyclin & Mantle Cell Marker), Monoclonal Antibody
| Product Name | Anti-Cyclin D1 (G1-Cyclin & Mantle Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. |
| Synonyms | B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1 oncogene, CCND1 protein, CCND1/FSTL3 fusion gene, CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene, CCND1/PTH fusion gene, cD1, Cyl 1, G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DCS-6 |
| Immunogen | Human full length recombinant cyclin D1 protein |
| Isotype | IgG2a, kappa |
| Reactivity | Human, Mouse, Primate, Rat |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 595 |
| Uniprot | P24385 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Lukas J, et. al. Oncogene, 1994, 9(3):707-18.Gillett C, et. al. Cancer Research, 1994, 54(7):1812-7.Bartkova J, et. al. Journal of Pathology, 1994, 172(3):237-45 |
| Supplier | ARP |
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