| Product Name | Anti-Cyclin D1 Protein Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. DCS-6 is especially useful in tumor diagnosis: it can be used as fast method to identify cases with 11q13 amplifications. Cyclin D1 gene is identical to the BCL-1 and the PRAD-1 oncogene and is part of the chromosome 11q13 amplicon which is amplified in several common tumor types like breast, lung, esophagus, urinary bladder and head and neck carcinoma. Polypeptide reacting: Mr 36 000 polypeptide (cyclin D1 polypeptide of human cells). |
| Synonyms | BCL1, PRAD1, U21B31, D11S287E |
| Clonality | Monoclonal |
| Clone | DCS-6 |
| Immunogen | Human Recombinant full-length cyclin D1 protein |
| Isotype | IgG2a |
| Specificity | DCS-6 reacts specifically with cyclin D1 protein present predominantly in G1 phase of cell cycle; it does not cross-react with D2 or D3 cyclins (the closest relatives within the cyclin family) |
| Reactivity | Canine, Human, Mouse, Primate, Rat |
| Applications | WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Lukas, J. et al. (1994) Oncogene 4: 707-718.Bartkova, J. et al. . (1994)J. Pathol. 172: 237-245.Bartkova, J. et al. (1994) Int. J. Cancer 57:353-361.Mueller, H.et al. (1994) Proc. Natl. Acad. Sci. USA, 91:2945.Lukas, J.et al. . (1994) J. CellBiol 125 (3): 625-638. |
| Background | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
| Supplier | ARP |
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