| Product Name | Anti-Cyclin E1 Antibody [rCCNE1/4936] - BSA and Azide free |
|---|---|
| Description | Recombinant mouse monoclonal [rCCNE1/4936] antibody to Cyclin E1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | rCCNE1/4936 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 10-176, of human Cyclin E1. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 53 kDa |
| Target | Cyclin E1 |
| Specificity | Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. |
| Reactivity | Human |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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