| Product Name | Anti-Cytokeratin/Keratin K10 Monoclonal Antibody |
|---|---|
| Description | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. Mab RKSE 60 recognizes of keratinizing cells in squamous cell carcinomas from epidermis, lung, bladder, cervix, esophagus, etc. |
| Synonyms | BIE, EHK, K10, KPP, BCIE, CK10 |
| Clonality | Monoclonal |
| Clone | RKSE 60 |
| Immunogen | Isolated from human skin |
| Isotype | IgG1 |
| Specificity | 56.6 kD cytokeratin 10 |
| Reactivity | Bovine, Canine, Human, Rabbit, Rat |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Herman, C et al. Am J Pathol 120: 419-426 (1985), Smedts, F et al. Am J Pathol 136: 657-668 (1990), Langbein, L et al. Eur J Cell Biol 82: 385-400 (2003) |
| Background | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. |
| Supplier | ARP |
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