Anti-Cytokeratin/Keratin K5/K8 (Pan Epithelial) Monoclonal Antibody
| Product Name | Anti-Cytokeratin/Keratin K5/K8 (Pan Epithelial) Monoclonal Antibody |
|---|---|
| Description | Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Keratin, type II cytoskeletal 5 also known as KRT5 is a protein that in human is encoded by the KRT5 gene. Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. The antibody can be used for the discrimination of carcinomas from non-epithelial tumors such as lymphomas, sarcomas and neural tumors. RCK 102 is applicable on frozen and paraffin embedded tissue. Formalin fixation may cause antigen denaturation or masking. Therefore, protease digestion is necessary prior to antibody application. |
| Synonyms | K5, CK5, DDD, DDD1, EBS2, KRT5A, K8, KO, CK8, CK-8, CYK8, K2C8, CARD2 |
| Clonality | Monoclonal |
| Clone | RCK 102 |
| Immunogen | Lung Cancer Cell Prep |
| Isotype | IgG1 |
| Specificity | Mab RCK 102 directed against the 58 kDa and 52.2 kDa cytokeratin/keratin proteins, reacts with all epithelial cell types. No reaction is observed in non-epithelial tissues. |
| Reactivity | Human, Mouse, Rabbit, Mammal |
| Applications | IF, IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Broers JLV et al. (1986) J. Cell Science, 83: 37-60 , Eyken P van (1990) Human Pathology, 21: 302-308 |
| Background | Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Keratin, type II cytoskeletal 5 also known as KRT5 is a protein that in human is encoded by the KRT5 gene. Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. |
| Supplier | ARP |
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