| Product Name | Anti-Cytokeratin/Keratin K13 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. Mab 1C7 specifically recognizes cytokeratin 13 (54 kD polypeptide) present in non-cornifying squamous epithelia and in transitional epithelium of the bladder. Epidermal cell culture studies have shown that cytokeratin 13 expression is involved in either the number or the strength of desmosomal contacts between supra basal cells of stratified quamous epithelia. |
| Synonyms | K13, CK13 |
| Clonality | Monoclonal |
| Clone | 1C7 |
| Immunogen | Keratin preparation from human esophagus |
| Isotype | IgG2a |
| Specificity | 54 kD polypeptide |
| Reactivity | Human, Mouse, Rabbit, Rat, Mammal |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Van Muijen, GNP. Et al. (1986) Exp. Cell Res. 162: 97-113 Kopan, R. et al. J. Cell Biol. 105: 427-440 |
| Background | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. |
| Supplier | ARP |
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