| Product Name | Anti-Cytokeratin/Keratin K19 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. Mouse Monoclonal Antibody to Cytokeratin/Keratin K19, human |
| Synonyms | CK19, K19, K1CS |
| Clonality | Monoclonal |
| Clone | RCK108 |
| Immunogen | Human Bladder Cell Line T24 |
| Isotype | IgG1 |
| Specificity | Mab RCK108 specifically reacts with cytokeratin/keratin K19 (40 kDa protein in immunoblotting), found in most simple and non-keratinized stratified epithelia. |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Hyberidoma culture Supernatant |
| Storage | 2-8C |
| References | Smedts, F. et al. (1990) Am. J. Pathol., 136: 657-668 |
| Background | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21 |
| Supplier | ARP |
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