| Product Name | Anti-Cytokeratin/Keratin K7 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. OVTL-12-30 decorates specific subtypes of adenocarcinoma. Cytokeratin 7 was found to occur in the columnar and glandular epithelium of the lung, cervix, breast, bile ducts, larger collecting ducts of the kidney and in mesothelium, but is absent from gastrointestinal epithelium, hepatocytes and myoepithelium. Several types of adenocarcinomas of the gastrointestinal tract and of the urinary tract are negative, while adenocarcinomas of the mammary gland, ovary and lung are positive. |
| Synonyms | K7, CK7, SCL, K2C7 |
| Clonality | Monoclonal |
| Clone | OVTL 12/30 |
| Immunogen | Isolated from Cell line T24 (human bladder carcinoma) |
| Isotype | IgG1 kappa |
| Specificity | In Immunoblotting reactive with the 54 kD cytokeratin 7 protein |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Niekerk, CC van et al. J. Pathol. 165: 145-152Van de Molengraft, FJ et al. (1993) Histopathology 22: 35-38Baars, JH. Et al. (1994) Am J Clin Pathol 101: 257-261Hernandez, BY. Et al. (2005) Human Pathology 36: 275-281 |
| Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. |
| Supplier | ARP |
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