| Product Name | Anti-Cytokeratin/Keratin Type I Monoclonal Antibody |
|---|---|
| Description | Type I keratins (or Type I cytokeratins) constitutes the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. Most of the type I keratins consist of acidic, low molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues.Type I keratins are encoded on chromosome 17q and encompasses: K9, K10, K11, K12, K13, K14, K15, K16, K17, K18, K19 and K20. Their molecular weight ranges from 40 kDa (K19) to 64 kDa (K9). Polypeptide reacting: MR 40,000, MR 48,000, and MR 50,000 polypeptides of human epithelial proteins (cytokeratins # 19,16,14) and most other acidic (type 1) cytokeratins. Mouse Monoclonal Antibody to Keratin type I. Polypeptide reacting: MR 40,000, MR 48,000, and MR 50,000 polypeptides of human epithelial proteins (cytokeratins # 19,16,14) and most other acidic (type 1) cytokeratins. |
| Clonality | Monoclonal |
| Clone | AE 1 |
| Immunogen | Human epidermal keratin |
| Isotype | IgG1 |
| Specificity | AE 1 represents an excellent marker for distinguishing carcinomas from non-epithelial tumors. |
| Reactivity | Gallus, Bovine, Canine, Human, Mouse, Primate, Rabbit, Rat |
| Applications | WB |
| Form | Purified (Ion-exchange), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Battifora, H.et al. (1984) Cancer 54: 843-848Eichner, R.et al. (1984) J. Cell Biol. 98: 1388-1396Garin-Chesa, P.et al. (1986) Am. J. Surg. Pathol. 10: 829-835Nelson, W.G. et al. (1984)Cancer Res. 44: 1600-1603Nelson, W.G. and Sun, T.-T. (1983) J. Cell Biol. 97: 244-251Moll, R. et al. (1982) Cell 31: 11-24Shi, S.-R.et al. (1984) Am. J. Pathol. 117: 53-63Sun, T.-T. et al. (1984) The Cancer Cell 1: 169-176Sun, T.-T. et al. (1983) J. Invest. Dermatol. 81: 109-115Sun, T.-T. et al. (1985)A review. In: Intermediate Filaments. The New York Acad. Sci (E. Wang, D.et al. eds.) 455: 307-329Tseng, S.C.G.et al. (1982) Cell 30: 361-372Woodcock-Mitchell, J. et al. (1982) J. Cell Biol. 95: 580-588Weiss, R.A.et al. (1984) J. Cell Biol. 98: 1397-1406Weiss, R.A. et al. (1983) J. Invest. Dermatol. 81: 2279-2286 |
| Background | Type I keratins (or Type I cytokeratins) constitutes the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. Most of the type I keratins consist of acidic, low molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues.Type I keratins are encoded on chromosome 17q and encompasses: K9, K10, K11, K12, K13, K14, K15, K16, K17, K18, K19 and K20. Their molecular weight ranges from 40 kDa (K19) to 64 kDa (K9). Polypeptide reacting: MR 40,000, MR 48,000, and MR 50,000 polypeptides of human epithelial proteins (cytokeratins # 19,16,14) and most other acidic (type 1) cytokeratins |
| Supplier | ARP |
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