| Product Name | Anti-Cytokeratin/Keratin K3/K76 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. Mouse Monoclonal Antibody to Keratin K3/K76. Polypeptide reacting: Mr 64 000 polypeptide (keratin K3; formerly also designated cytokeratin 3) of human corneal epithelium and keratin K76 (formerly also designated cytokeratin K2p) of palate epithelium. |
| Synonyms | K3, CK3, KRT76, KRT2B, KRT2P, HUMCYT2A |
| Clonality | Monoclonal |
| Clone | AE5 |
| Immunogen | Human epidermal keratin |
| Isotype | IgG1 |
| Specificity | AE 5 represents an excellent marker for corneal type differentiation. Positive for epithelial cells of cornea, snout and some oral mucosa. This antibody has been used for studying corneal epithelial stem cells |
| Reactivity | Bovine, Human, Rabbit |
| Applications | WB |
| Form | Purified (Ion-exchange), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Cooper, D. et al. (1985) Lab Invest 52: 243-256Schermer, A. et al. (1986) J. Cell Biol. 103: 49-62Sun, T.-T.et al. (1984) The Cancer Cell 1: 169-176Moll R et al. (1982) Cell 31: 11-24 |
| Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| Supplier | ARP |
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