| Product Name | Anti-Cytokeratin/Keratin K19 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. Mouse Monoclonal Antibody to Cytokeratin/Keratin K19. Polypeptide reacting: MR 40,000 polypeptide (cytokeratin #19) of human glandular epithelia. |
| Synonyms | K19, CK19, K1CS |
| Clonality | Monoclonal |
| Clone | Ks 19.2 (Z105.6), also published as BM 19.21, MAK 19.21 |
| Immunogen | Keratin K19 of Mr 40 000; from cultured human MCF-7 cells |
| Isotype | IgG2b |
| Specificity | Ks 19.2 represents an excellent marker to discriminate glandular epithelial CA from those of different origin. No reaction with hepatocellular CA! Tumors specifically detected: All tested adeno CA; cholangio CA of liver; renal cell CA; transitional cell CA of the bladder; ovary CA; squamous cell CA of cervix, bronchus and lung (intermediate type); mesothelioma; carcinoid tumor of bronchus; breast CA; thymoma. |
| Reactivity | Amphibian, Gallus, Aves, Bovine, Fish, Human, Rabbit, Rat |
| Applications | WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Bader, B.L. & Franke, W.W. (1990) Differentiation 45: 109-118 Bader, B.L., et al. (1988) Eur. J. Cell Biol. 47: 300-319Bosch, F.X., et al. (1989) Virchows Arch. B Cell Pathol. 58: 59-77Bosch, F.X.,et al. (1988) J. Cell Biol. 106: 1635-1648Dockhorn-Dworniczak, B. et al. (1987) Differentiation 35: 53-71Heid, H.W. et al. (1988) Differentiation 37: 137-157Heid, H.W. et al. (1988) Differentiation 37: 215-230 (1988)Moll, R. et al. (1982) Cell 31: 11-24Moll, I. et al . (1988) J. Invest. Dermatol. 91: 251-257Moll, I. & Moll, R. (1991) Arch Dermatolo Res 283: 300-309Moll, R et al (1990) J. Cell Biol. 111: 567-580 |
| Background | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. |
| Supplier | ARP |
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