| Product Name | Anti-Cytokeratin/Keratin 2 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. Mouse Monoclonal Antibody to Cytokeratin/Keratin 2. Ks 2.342.7.4 represents an excellent marker to study terminal epidermal differentiation. Polypeptide reacting: Basic human keratin K2 (MW 65,852; formerly also designated cytokeratin 2e). |
| Synonyms | K2e, KRTE, CK-2e, KRT2A, KRT2E, KRT2 |
| Clonality | Monoclonal |
| Clone | Ks 2.342.7.4 |
| Immunogen | Synthetic peptide (N-terminal amino acids nos. 2-23) of human keratin K2 (MW 65,852) |
| Isotype | IgG1 |
| Specificity | The mab is reactive with epidermal cells in uppermost suprabasal layers including scalp, foot and sole. It recognizes individual cells within epidermis of tongue and mamille (co-localization with keratin K10). It is also reactive on hyperkeratosis of diverse viral and genetic origin.The mab does not react with palate keratin K76. |
| Reactivity | Bovine, Human |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Collin, C. et al. (1992). Exp. Cell Res. 202: 132-141Swensson o et al. (1998) Br J Dermatol 139: 767-775 |
| Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| Supplier | ARP |
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