Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin), Monoclonal Antibody
| Product Name | Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. |
| Synonyms | CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | LHK6; same as LHK6B |
| Immunogen | A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from C-terminus of human keratin 6 |
| Isotype | IgG2a, kappa |
| Reactivity | Human, Mouse |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3853-KRT6A, 3854-KRT6B, 286887-KRT6C |
| Uniprot | P02538-KRT6A, P04259-KRT6B, P48668-KRT6C |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Wetzels RH, et. al. American Journal of Pathology, 1991, 138(3):751-63 |
| Supplier | ARP |
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