Anti-Cytokeratin 14 (KRT14) (Squamous Cell Marker), Monoclonal Antibody
| Product Name | Anti-Cytokeratin 14 (KRT14) (Squamous Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast. |
| Synonyms | CK-14, Dowling Meara, ebs3, ebs4, Epidermolysis Bullosa Simplex, k14, Keratin 14, Keratin Type I Cytoskeletal 14, Koebner, krt14, NFJ |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | KRT14/532 |
| Immunogen | Recombinant full-length human KRT14 protein |
| Isotype | IgG3 |
| Reactivity | Human, Mouse, Rat |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3861 |
| Uniprot | P02533 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | van der Velden, L.A., et al. 1993. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview. Head and Neck 15:133-146. Chen, H., et al. 1995. Keratin 14 gene mutations in patients with epidermolysis bullosa simplex. J. Invest. Dermatol. 105: 629-632 |
| Supplier | ARP |
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