| Product Name | Anti-Cytokeratin 10 Antibody [KRT10/1948R] |
|---|---|
| Description | Recombinant rabbit monoclonal [KRT10/1948R] antibody to Cytokeratin 10. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | KRT10/1948R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human KRT10 protein. |
| Isotype | IgG |
| Molecular Weight | 56.5 kDa |
| Target | Cytokeratin 10 |
| Specificity | This antibody recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts. |
| Reactivity | Canine, Feline, Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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