| Product Name | Anti-Cytokeratin 6A Antibody [KRT6/3997R] - BSA and Azide free |
|---|---|
| Description | Recombinant rabbit monoclonal [KRT6/3997R] antibody to Cytokeratin 6A. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | KRT6/3997R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment corresponding to human Cytokeratin 6. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 56 kDa |
| Target | Cytokeratin 6A |
| Specificity | Cytokeratin 6 is an epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. This protein always paired with the type-I keratin K16.Cytokeratin 6 have been identified in epidermis only in samples from plantar glabrous skin while in hairy skin this keratin appeared to be absent in interfollicular epidermis but were clearly present in hair follicle outer root sheath, and this protein also consistently expressed in non-keratinizing stratified squamous epithelia. Among tumors, cytokeratin 6 is typically and strongly expressed in squamous cell carcinomas of different sites, preferentially in inner, maturing layers of the tumor cell nests.Cytokeratin 6 is always used with cytokeratin 5 and is a useful aid for classification of epithelioid mesotheliomas. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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