Anti-Cytokeratin 17 Antibody [KRT17/8346R] - BSA and Azide free
| Product Name | Anti-Cytokeratin 17 Antibody [KRT17/8346R] - BSA and Azide free |
|---|---|
| Description | Recombinant rabbit monoclonal [KRT17/8346R] antibody to Cytokeratin 17. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | KRT17/8346R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment of human KRT17 protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 46 kDa |
| Target | Cytokeratin 17 |
| Specificity | CK17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glandssuch as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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