| Product Name | Anti-Cytokeratin/Keratin K18 Monoclonal Antibody |
|---|---|
| Description | KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Ks 18.27 represents an excellent marker to discriminate simple epithelia from those of different origin. Polypeptide reacting: Mr 45,000 polypeptide (keratin K18; formerly also designated cytokeratin 18) of all simple type and complex epithelia. |
| Synonyms | K18, CYK18 |
| Clone | Ks 18.27 |
| Immunogen | Cytoskeletal preparation from human tumor cell line MCF-7 |
| Isotype | IgG1 |
| Specificity | Tumors Specifically Detected: All adeno-CA tested; undifferentiated CA; cervix CA; hepatocellular CA |
| Reactivity | Bovine, Human |
| Applications | WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Bosch, F.X. et al. (1989) Cell Pathol. 58: 59-77Moll, R. et al. (1988) Am. J. Pathol. 132: 123-144Moll, R. et al (1982) Cell 31: 11-24Moll, R. J. et al. (1990) Cell Biol. 111: 567-580 |
| Supplier | ARP |
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