| Product Name | Anti-Cytokeratin/Keratin K19 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. Ks 19.2 represents an excellent marker to discriminate simple epithelial carcinoma from those of different origin. Polypeptide Reacting: Mr 40 000 polypeptide (keratin K19; formerly also designated cytokeratin 19) of human glandular epithelia. The epitope has been localized on aa. 352-368 (VRADSERQNQEYQRLMD) of the alpha-helical fragment. |
| Synonyms | K19, CK19, K1CS |
| Clone | Ks 19.2 (Z105.6) |
| Immunogen | Cytokeratin/Keratin K19 of Mr 40000; from cultured human MCF-7 cells |
| Isotype | IgG2b |
| Specificity | All tested adenocarcinoma; cholangio ca. of liver; renal cell ca.; transitional cell ca. of the bladder; ovary ca.; squamous cell ca. of cervix, bronchus and lung (intermediate type); mesothelioma; carcinoid tumor of bronchus; breast ca.; thymoma. |
| Reactivity | Amphibian, Gallus, Bovine, Fish, Human, Rabbit, Rat |
| Applications | WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Bader, B.L. & Franke, W.W. (1990) Differentiation 45: 109-118 Bader, B.L., et al. (1988) Eur. J. Cell Biol. 47: 300-319 Bosch, F.X., et al. (1989) Virchows Arch. B Cell Pathol. 58: 59-77 Bosch, F.X.,et al. (1988) J. Cell Biol. 106: 1635-1648 Dockhorn-Dworniczak, B. et al. (1987) Differentiation 35: 53-71 Heid, H.W. et al. (1988) Differentiation 37: 137-157 Heid, H.W. et al. (1988) Differentiation 37: 215-230 (1988) Moll, R. et al. (1982) Cell 31: 11-24 Moll, I. et al . (1988) J. Invest. Dermatol. 91: 251-257 Moll, I. & Moll, R. (1991) Arch Dermatolo Res 283: 300-309 Moll, R et al (1990) J. Cell Biol. 111: 567-580 |
| Supplier | ARP |
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