| Product Name | Anti-DC-SIGN Antibody [MR-1] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [MR-1] antibody to DC-SIGN. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MR-1 |
| Conjugate | Unconjugated |
| Immunogen | Immature myeloid monocyte-derived dendritic cells (MDDCs). |
| Isotype | IgG1 |
| Target | DC-SIGN |
| Specificity | This antibody recognises human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a ~45 kDa C-type lectin that binds ICAM-3 also known as CD209. CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro.CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's. Mouse anti Human CD209 antibody, clone MR-1 is reported to partially block the functional activity of DC-SIGN (Melero et al.). |
| Reactivity | Human |
| Applications | FA, FC, IF |
| Working Dilutions | Flow Cytometry: 1:50 - 1:100, Use 10µl of the suggested working dilution to label 106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline. |
| Concentration | 1 mg/ml |
| Storage | Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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