| Product Name | Anti-Dectin-1 Antibody [BD6] |
|---|---|
| Description | Mouse monoclonal [BD6] antibody to Dectin-1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BD6 |
| Conjugate | Unconjugated |
| Immunogen | NIH/3T3 cells expressing full length Beta-glucan receptor. |
| Isotype | IgG2b |
| Target | Dectin-1 |
| Specificity | This antibody recognises human Dectin-1, also known as beta-glucan receptor (ßGR) or CD369. Dectin-1 is a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells.Human Dectin-1 has two major (ßGR-A and ßGR-B) and several minor isoforms. ßGR-A and ßGR-B differs by the presence and absence, respectively, of a stalk region. recognises ßGR-A only. |
| Reactivity | Human |
| Applications | FC |
| Working Dilutions | Flow Cytometry: 1:25 - 1:200, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl. |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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