| Product Name | Anti-Desmocollin 3 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. Mouse Monoclonal Antibody to Human Desmocollin 3. Polypeptide reacting: 09 kD and 100 kD polypeptides (desmocollin 3 splice isoforms at pI 5.2) from human epidermal desmosomes. |
| Synonyms | DSC, DSC1, DSC2, DSC4, CDHF3, HT-CP |
| Clonality | Monoclonal |
| Clone | Dsc3-U114 |
| Immunogen | Synthetic peptide corresponding to sequence present on the extracellular anchor domain of human desmocollin 3 |
| Isotype | IgG1 |
| Specificity | Mab localizes Dsc3 present inall living epidermal layersin glandular duct cellsin basal matrix cells and outer root sheath of hair folliclesbasal and suprabasal cell layers of stratified epithelia (e.g. vagina, tongue, esophagus), basal layer of bladder urothelium and complex epithelium of tracheathymic reticulum cells. All simple epithelia are negative. Intercalated disks of myocardium are negative |
| Reactivity | Human |
| Applications | IF, IHC, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | 1. Nuber, U.A., et al. (1996) Eur. J. Cell Biol.66: 69-74 2. SchÌÄå_fer, S. & Franke, W.W. (1996) Differentiation 60: 99-108 3. Hatzfeld M et al. (2000) J Cell Biol 149: 209-222 4. Moll I et al. (1999) Arch Dermatol Res 291: 437-446 5. Kurzen H et al. (1998) Differentiation 63: 295-304 6. South AP et al. (2003) J Cell Sci 116: 3303-3314 7. Akat K et al. (2003) Acta Neuropathol 106: 337-347 |
| Background | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. |
| Supplier | ARP |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
