| Product Name | Anti-Desmoglein 3 Monoclonal Antibody |
|---|---|
| Description | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. Mouse Monoclonal Antibody to Desmoglein 3. |
| Synonyms | PVA, CDHF6, DSG3 |
| Clonality | Monoclonal |
| Clone | Dsg-G194 |
| Immunogen | Recombinant Recombinant human polypeptide Desmoglein 3 (C-terminal aa 920-940 VSIPDPLQHGNYLVTETYSAS)human polypeptide Desmoglein 3 |
| Isotype | IgG1 |
| Specificity | In immunoblots of cytoskeletal preparations from human epidermis the antibody reacts specifically with a 140 kD polypeptide typical for Desmoglein 3. In immunolocalization studies the mab shows typical staining of basal and lower suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles. The staining pattern ob- served corresponds to those obtained with pemphigus vul- garis patient sera. Cross-reaction with Desmogleins 1 and 2 was not detected |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Kurzen, H.et al. (1998) Differentiation 63: 295-304SchÌÄå_fer, S. et al. (1996) Differentiation 60: 99-108 |
| Background | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. |
| Supplier | ARP |
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