| Product Name | Anti-Desmoglein 3 Antibody [DSG3/2839] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [DSG3/2839] antibody to Desmoglein 3. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DSG3/2839 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 379-491, human DSG3 protein. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 130 kDa |
| Target | Desmoglein 3 |
| Specificity | This antibody recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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