| Product Name | Anti-DMRT2 Antibody [PCRP-DMRT2-1B11] |
|---|---|
| Description | Mouse monoclonal [PCRP-DMRT2-1B11] antibody to DMRT2. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-DMRT2-1B11 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human DMRT2 protein. |
| Isotype | IgG2b |
| Molecular Weight | 62 kDa |
| Target | DMRT2 |
| Specificity | The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). |
| Reactivity | Human |
| Applications | FC, WB |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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