| Product Name | Anti-DNMT3A Antibody [PCRP-DNMT3A-1E2] |
|---|---|
| Description | Mouse monoclonal [PCRP-DNMT3A-1E2] antibody to DNMT3A. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-DNMT3A-1E2 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human DNMT3A protein. |
| Isotype | IgG1 |
| Molecular Weight | 102 kDa |
| Target | DNMT3A |
| Specificity | The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000 full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Sadenosyl-L-methionin |
| Reactivity | Human |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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