| Product Name | Anti-DOPA Decarboxylase / DDC Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to DOPA Decarboxylase / DDC. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | SDS denatured, recombinant bovine DOPA decarboxylase expressed E. coli and purified from inclusion bodies. |
| Isotype | IgG |
| Molecular Weight | Approximately 55 kDa in rat adrenal medulla. |
| Target | DOPA Decarboxylase / DDC |
| Specificity | This antibody recognises DOPA decarboxylase, also known as aromatic-L-amino acid decarboxylase or DDC), an enzyme that catalyses the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. The enzyme is expressed ubiquitously and is essential for the formation of catecholamines, indoleamines and trace amines. DDC is considered to be the rate-limiting step for the formation of trace amines, but not for the formation of catecholamines or indoleamines. It also becomes rate-limiting for dopamine formation in Parkinson's disease patients treated with L-DOPA. |
| Reactivity | Bovine, Rat |
| Applications | WB |
| Working Dilutions | WB: 1:1,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM HEPES, pH 7.5, with 150mM NaCl, 0.01% BSA, 50% Glycerol, and 0.05% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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