| Product Name | Anti-E-Cadherin Monoclonal Antibody |
|---|---|
| Description | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. In epithelia, E-cadherin is involved in the development and maintenance of the cell layers during embryogenesis and in the adult tissue. Clustering of E-cadherin seems to occur via a, b and g catenins, which link E-cadherin to cytoskeletal actin. Loss of E-cadherin expression seems to be correlated with the transformation state of carcinoma cells and with their metastatic potential. |
| Synonyms | UVO, CDHE, ECAD, LCAM, Arc-1, CD324 |
| Clone | AR.EC1 |
| Immunogen | Synthetic peptide part of human origin |
| Isotype | IgG1 |
| Specificity | E-cadherin |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| Form | Purified, in PBS, containing 0.1% stabilizer, and 0.1% Sodium azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| Supplier | ARP |
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