| Product Name | Anti-Endothelin 1 Antibody [IC4] |
|---|---|
| Description | Mouse monoclonal [IC4] antibody to Endothelin 1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | IC4 |
| Conjugate | Unconjugated |
| Immunogen | C-terminus fragment of human endothelin 1. |
| Isotype | IgG1 |
| Target | Endothelin 1 |
| Specificity | This antibody recognises human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothlin converting enzyme to produce the active endothelin-1 (21aa) peptide and a C-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular mass of approximately 25 kDa. Mouse anti human endothelin 1 antibody, clone IC4 shows less than 10% reactivity with endothelin 3.Plasma levels of both endothlin-1 and big endothlin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0 mins) and measurement of big-endothlin-1 may be a more reliable measure of the endothlin secretory pathway activity (Hemsén et al. 1995). |
| Reactivity | Human |
| Applications | IHC-Fr, IRMA |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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