Anti-Ep-CAM / CD326 (Epithelial Marker), Monoclonal Antibody
| Product Name | Anti-Ep-CAM / CD326 (Epithelial Marker), Monoclonal Antibody |
|---|---|
| Description | Binding epitope of this antibody is located in the first EGF-like repeat domain (EGF1) between amino acids 27-59 of Ep-CAM._EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. |
| Synonyms | Adenocarcinoma-associated Antigen, Cell Surface Glycoprotein Trop-1, EGP2, EGP314, EGP40, Epithelial Cell Adhesion Molecule, Epithelial Glycoprotein 314, ESA, KSA, TACD1, TROP1, Tumor-associated Calcium Signal Transducer 1 (TACSTD1), ECS-1, Epidermal Surface Antigen 1, ESA1, FLOT2, Flotillin-2, Membrane Component, Chromosome 17, Surface Marker-1 (M17S1), REG-1, Reggie-1, Reggie-2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MOC-31 |
| Immunogen | Neuraminidase treated GLS-1 human small cell lung carcinoma cells |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4072 |
| Uniprot | P16422 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Myklebust AT, Beiske K, Pharo A, Davies CD, Aamdal S, Fodstad O: Selection of anti-SCLC antibodies for diagnosis of bone marrow metastasis. Br J Cancer Suppl 1991, 14:49-53Manon J. Winter, Iris D. Nagtegaal, J. Han J. M. van Krieken, and Sergey V. Litvinov. The Epithelial Cell Adhesion Molecule (Ep-CAM) as a Morphoregulatory Molecule Is a Tool in Surgical Pathology. J Biol Chem 125:437-446 (1994) |
| Supplier | ARP |
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