| Product Name | Anti-Epstein-Barr Virus LMP2A Antibody [15F9] |
|---|---|
| Description | Rat monoclonal [15F9] antibody to Epstein-Barr Virus LMP2A. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 15F9 |
| Conjugate | Unconjugated |
| Immunogen | Bacterial TrpE-LMP2A fusion protein. |
| Isotype | IgG1 |
| Target | Epstein-Barr Virus LMP2A |
| Specificity | This antibody recognises latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpesvirus, which is associated with conditions such as Hodgkin’s disease and Burkitt’s Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. recognises LMP2A and does not cross react with LMP2B. |
| Reactivity | Virus |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1:100 - 1:1,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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