| Product Name | Anti-Estrogen Receptor Monoclonal Antibody |
|---|---|
| Description | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. Estrogen Receptor can be detectedin up to 70% of breast carcinomas. The quantity of estrogen receptor protein is important for prognosis and treatment of breast cancer. Mab LH01 shows nuclear, no cytoplasmic staining. |
| Synonyms | ER, ESR, Era, ESRA, ESTRR, NR3A1 |
| Clonality | Monoclonal |
| Clone | CC4-5 |
| Immunogen | Synthetic peptide |
| Isotype | IgG1 |
| Specificity | Estrogen Receptor can be detected in up to 70% of breast carcinomas |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Clark, GM et al. (1989) Proc Royal Society Edinburgh. 95B: 145-150Mason, BH et al. (1983) Cancer Research 43: 2985-2990 |
| Background | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. |
| Supplier | ARP |
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