Anti-Estrogen Receptor alpha Antibody [ESR1/6983R] - BSA and Azide free
| Product Name | Anti-Estrogen Receptor alpha Antibody [ESR1/6983R] - BSA and Azide free |
|---|---|
| Description | Recombinant rabbit monoclonal [ESR1/6983R] antibody to Estrogen Receptor alpha. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | ESR1/6983R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 495-595, of human Estrogen Receptor alpha. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | ~67 kDa |
| Target | Estrogen Receptor alpha |
| Specificity | Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.Studies have shown ER α is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas.Studies with immunohistochemical assay show that positive steroid hormone status has predicted favorable overall, survival, independently of hormonal treatment. Secondly, ER α can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas. |
| Reactivity | Human |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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