| Product Name | Anti-Factor I / CFI Antibody [052.11.3 (3R/8)] |
|---|---|
| Description | Mouse monoclonal [052.11.3 (3R/8)] antibody to Factor I / CFI. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 052.11.3 (3R/8) |
| Conjugate | Unconjugated |
| Immunogen | Native human factor I from serum. |
| Isotype | IgG1 |
| Target | Factor I / CFI |
| Specificity | This antibody recognises complement factor I, a member of the peptidase S1 family present in the blood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors.Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome. Mouse anti Human Complement Factor I antibody, clone 3R/8 blocks function of complement factor I.Removal of Sodium Azide is recommended prior to use in functional assays. |
| Reactivity | Human |
| Applications | IHC-Fr, ELISA, FA, FC, WB |
| Working Dilutions | ELISA: 1:500 - 1:4,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Borate Buffered Saline with 0.1% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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