| Product Name | Anti-Factor VII Antibody [F7/3515] |
|---|---|
| Description | Mouse monoclonal [F7/3515] antibody to Factor VII. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | F7/3515 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 366-466) of human F7 protein. |
| Isotype | IgG2 |
| Molecular Weight | 200 kDa / 80 kDa / 73 kDa / 50 kDa / 43 kDa |
| Target | Factor VII |
| Specificity | Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels. |
| Reactivity | Human |
| Applications | ELISA, IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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