| Product Name | Anti-FANCM Monoclonal Antibody |
|---|---|
| Description | Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk. |
| Synonyms | Fanconi Anemia Complementation Group M, KIAA1596, Fanconi Anemia-Associated Polypeptide Of 250 Kda, ATP-Dependent RNA Helicase FANCM, Protein Hef Ortholog, FAAP250 |
| Host | Mouse |
| Clone | M40-P2C6 |
| Immunogen | Peptide Sequence - MLPNDLNQDR (amino acids 2069 -2078) |
| Isotype | IgG1 kappa |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Background | Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk. |
| Supplier | Vertebrate Antibodies Limited |
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