| Product Name | Anti-Fas Ligand Antibody [FASLG/4456] |
|---|---|
| Description | Mouse monoclonal [FASLG/4456] antibody to Fas Ligand. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | FASLG/4456 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 107-222, of human Fas Ligand. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 26 kDa (soluble FAS-L) / 40 kDa (FAS-L membrane) |
| Target | Fas Ligand |
| Specificity | Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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