| Product Name | Anti-Fas Ligand Antibody [14C2] |
|---|---|
| Description | Mouse monoclonal [14C2] antibody to Fas Ligand. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 14C2 |
| Conjugate | Unconjugated |
| Isotype | IgG1 |
| Target | Fas Ligand |
| Specificity | This antibody recognises the human CD178, also known as Tumor necrosis factor ligand superfamily member 6, Fas ligand (FasL), Apoptosis antigen ligand or CD95 ligand. CD178 is a 281 amino acid, a ~40 kDa single pass type-II transmembrane glycoprotein bearing a single intracellular FasL domain and member of the tumor necrosis factor family. CD178 is expressed by activated T lymphocytes and NK cells. The protein may exist as either a membrane bound or a cleaved soluble form. CD178 plays an important role in T cell mediated cytotoxicity. Binding of CD178 to Fas (CD95) results in the induction of apoptosis. Mouse anti human CD178 antibody, clone 14C2 is reported to recognize a conformation dependent non-blocking epitope on CD178. |
| Reactivity | Human |
| Applications | ELISA, FC, IP |
| Working Dilutions | FC 1: 1:25 - 1:50, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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