| Product Name | Anti-Fibroblast Activation Protein, alpha Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Fibroblast Activation Protein, alpha. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to a region within the extracellular domain of human FAP alpha, conjugated to Keyhole Limpet Haemocyanin. |
| Isotype | IgG |
| Target | Fibroblast Activation Protein, alpha |
| Specificity | This antibody recognises fibroblast activation protein alpha (FAP alpha), a type II membrane protein belonging to the serine protease family. FAP alpha is upregulated on activated fibroblasts in response to wounding, and may also be involved in epithelial-mesenchymal interactions during development and tissue repair. Active FAP alpha is a ~170 kDa homodimeric protein which can also exist as a soluble form. FAP alpha can also form heterodimeric complexes with CD26 (DPP4), and these proteins may function co-ordinately to modulate the growth, differentiation, adhesion and metastasis of tumour cells. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P 1: 10 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 500 µg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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