| Product Name | Anti-Filaggrin Antibody [FLG/3909R] |
|---|---|
| Description | Recombinant rabbit monoclonal [FLG/3909R] antibody to Filaggrin. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | FLG/3909R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 198-288, of human Filaggrin. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 26-45 kDa (Processed) / 350 kDa (Profilaggrin) |
| Target | Filaggrin |
| Specificity | Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery. |
| Reactivity | Human |
| Applications | WB |
| Working Dilutions | WB: 2-4 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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