| Product Name | Anti-GCET2 Antibody [HGAL/830] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [HGAL/830] antibody to GCET2. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HGAL/830 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 1-200, of human GCET2 protein. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 21 kDa |
| Target | GCET2 |
| Specificity | This antibody recognizes a protein of kDa, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL). |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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