| Product Name | Anti-GFAP Antibody [4A11] |
|---|---|
| Description | Mouse monoclonal [4A11] antibody to GFAP. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4A11 |
| Conjugate | Unconjugated |
| Immunogen | Bovine spinal cord homogenate. |
| Isotype | IgG2b |
| Target | GFAP |
| Specificity | This antibody recognises glial fibrillary acidic protein, or GFAP, a class III intermediate filament. During development of the central nervous system, GFAP distinguishes astrocytes from other glial cells. It is involved in various cellular functions, such as cell structure and movement, cell communication and the functioning of the blood-brain barrier. It also plays a role in mitosis by adjusting the filament network present in the cell. Defects in GFAP are a cause of Alexander disease, a rare disorder of the central nervous system affecting mostly males. It is a progressive leukoencephalopathy resulting in mental and physical retardation, dementia, seizures and early death. Mouse anti Bovine GFAP antibody, clone 4A11 may be used in conjunction with Mouse anti Bovine GFAP antibody, clone 1B4 (MCA4733) and Mouse anti Bovine GFAP antibody, clone 2E1 (MCA4734) for increased sensitivity when used in immunohistology. |
| Reactivity | Gallus, Bovine, Canine, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep |
| Applications | IHC-Fr, IHC-P, RIA, WB |
| Working Dilutions | WB: 1:500 - 1:10,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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