| Product Name | Anti-Glycine Receptor alpha 1 + alpha 2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Glycine Receptor alpha 1 + alpha 2. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to the N-terminus of rat glycine receptor alpha 1 subunit. |
| Isotype | IgG |
| Molecular Weight | Approximately 48 kDa in rat spinal cord lysates. |
| Target | Glycine Receptor alpha 1 + alpha 2 |
| Specificity | This antibody recognises an epitope within the N-terminal region of glycine receptor alpha 1 and alpha 2 subunits.Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation.Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain. |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-Fr, WB |
| Working Dilutions | IHC-Fr: 1:1,000, WB: 1:1,000 |
| Form | Lyophilized |
| Concentration | Reconstitution dependent. |
| Storage | Lyophilized: Store at 4°C. Reconstituted: Store at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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