| Product Name | Anti-GPRC5A Antibody [GPRC5A/7893] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [GPRC5A/7893] antibody to GPRC5A. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | GPRC5A/7893 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 200-357) of human GPRC5A protein. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 32 kDa |
| Target | GPRC5A |
| Specificity | Retinoic acid-induced protein 3 (RAI3) is an transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from RAI3 may have a place in breast cancer treatments. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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