| Product Name | Anti-GRAMD4 Antibody [PCRP-GRAMD4-1A10] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [PCRP-GRAMD4-1A10] antibody to GRAMD4. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-GRAMD4-1A10 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human GRAMD4 protein. |
| Isotype | IgG1 |
| Molecular Weight | 66 kDa |
| Target | GRAMD4 |
| Specificity | The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies. |
| Reactivity | Human |
| Applications | FC, IF |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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